Micro-Nanofluidique pour les sciences de la vie et de l’environnement

- mile -


L’équipe MILE aborde des questions de biophysique grâce aux technologies microfluidiques. Nous étudions le lien entre perméabilité, propriétés mécaniques, et activité biologique de tissus et cellules. Les applications vont du rôle de la mécanique dans les cancers, à la filtration et au tri cellulaire.


L’équipe aborde des questions de biophysique grâce aux technologies microfluidiques. Nos sujets de recherche sont explicités ci-dessous.

Impact du confinement spatial sur la physiologie cellulaire

Nous utilisons la microfluidique pour étudier l'impact du confinement sur le comportement de cellules vivantes.

+

Mécanique d'agrégats multicellulaires, et leurs interactions avec des nanoparticules

Nous développons une technologie fluidique originale de mesure des propriétés mécaniques d’agrégats cellulaires (micropipettes sur puce), fondamentales pour de nombreux processus biologiques.

+

Cellules et vésicules extracellulaires : Microfluidique pour leur purification et l'analyse de leur composition en acides nucléiques

Nous développons des technologies microfluidiques pour purifier des cellules et des vésicules extracellulaires.

+

Microvasculature sur puce : déformation, perméation et immunomodulation des vaisseaux lymphatiques et sanguins

Nous étudions les fonctions de barrière et d'immunomodulation de ces tissus vasculaires à l'aide de technologies d'organes sur puce.

+

(Bio)filtration sur puce, ou comment étudier les mécanismes de filtration à micro-échelle.

Nous étudions le biocolmatage grâce à des modèles microfluidiques de membranes de filtration

+

Dernières Publications

2025

Articles dans une revue

Diana Valverde-Mendez, Alp M Sunol, Benjamin P Bratton, Morgan Delarue, Jennifer L Hofmann, et al.. Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (4), pp.e2406340121. ⟨10.1073/pnas.2406340121⟩. ⟨hal-04915896⟩

Mickaël Di-Luoffo, Céline Schmitter, Emma C Barrere, Nicole Therville, Maria Chaouki, et al.. Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells. Life Science Alliance, 2025, 8 (3), pp.e202402854. ⟨10.26508/lsa.202402854⟩. ⟨hal-04874687⟩

2024

Articles dans une revue

Terence Desclaux, Leonardo Santana, Inès Verdeille, Paul Duru, Pierre Joseph, et al.. Hydrodynamic resistance of a yeast clog. Physical Review Fluids, 2024, 9 (3), pp.034202. ⟨10.1103/PhysRevFluids.9.034202⟩. ⟨hal-04224639v4⟩

Hyojun Kim, Baptiste Alric, Nolan Chan, Julien Roul, Morgan Delarue. Intracellular dry mass density increases under growth-induced pressure. Open Research Europe, 2024, 4, pp.231. ⟨10.12688/openreseurope.18557.2⟩. ⟨hal-04915889⟩

Jean Cacheux, Tadaaki Nakajima, Daniel Alcaide, Takanori Sano, Kotaro Doi, et al.. Protocol for fabricating and characterizing microvessel-on-a-chip for human umbilical vein endothelial cells. STAR Protocols, 2024, 5 (2), pp.102950. ⟨10.1016/j.xpro.2024.102950⟩. ⟨hal-04715098⟩

Daniel Alcaide, Baptiste Alric, Jean Cacheux, Shizuka Nakano, Kotaro Doi, et al.. Laminin and hyaluronan supplementation of collagen hydrogels enhances endothelial function and tight junction expression on three-dimensional cylindrical microvessel-on-a-chip. Biochemical and Biophysical Research Communications, 2024, 724 (6), pp.150234. ⟨10.1016/j.bbrc.2024.150234⟩. ⟨hal-04715111⟩

Thomas Perros, Anaïs Biquet-Bisquert, Zacchari Ben Meriem, Morgan Delarue, Pierre Joseph, et al.. Mechanical characterization of regenerating Hydra tissue spheres. Biophysical Journal, 2024, 123 (13), pp.1792-1803. ⟨10.1016/j.bpj.2024.05.022⟩. ⟨hal-04668523⟩

Sylvain Landiech, Marianne Elias, Pierre Lapèze, Hajar Ajiyel, Marine Plancke, et al.. Parallel on-chip micropipettes enabling quantitative multiplexed characterization of vesicle mechanics and cell aggregates rheology. APL Bioengineering, 2024, 8 (2), pp.026122. ⟨10.1063/5.0193333⟩. ⟨hal-04616249⟩

Chapitres d’ouvrages

Audrey Boutonnet, Inga Tijunelyte, Aurélien Bancaud, Frédéric Ginot. DNA Sizing with pg/μL Sensitivity for Cell-Free DNA Analysis with the μLAS Technology. Microfluidics Diagnostics, 2804, Springer US, pp.53-64, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3850-7_2⟩. ⟨hal-04783449⟩

Communications dans un congrès

Claire Lac, Pauline Thomas, Julie Foncy, Marjorie Fanjul, Laurent Malaquin, et al.. Tumoral mechanical stress reprograms adjacent tissue micro-environment to fuel pancreatic tumor progression: identification of a new subtype of activated fibroblasts.. Journée de l'Association Française pour la Recherche sur le Cancer du Pancréas., Sep 2024, Toulouse, France. ⟨hal-04834786⟩

Mickael Di-Luoffo. Oral bacteria accelerate pancreatic cancer development in mice. 38ième réunion du Club Français du Pancréas, Sep 2024, Toulouse, France. ⟨hal-04908702⟩

Sanzhar Aitbay, Hala Shalhoub, Romina D’Angelo, Nicole Therville, Silvia Arcucci, et al.. Mechanical stress & signal integration by PI3Ks for the control of tumour growth.. 4th PIPgen annual meeting, PIPgen, Sep 2024, Cambridge, United Kingdom. ⟨hal-04924047⟩

Romina D’Angelo, Silvia Arcucci, Nicole Therville, Celine Denais, Morgan Delarue, et al.. Imaging the 3D cellular effects of compression in oncology: Application in pancreatic cancer. Atelier pour le 1st meeting of the France-BioImaging Mechanobiology WG, Mechanobiology Working Group FBI, Dec 2024, Toulouse, France. ⟨hal-04908796⟩

Autres documents

Sanzhar Aitbay, Nicole Therville, Mickael Di-Luoffo, Hala Shalhoub, Romina D’Angelo, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. 48th FEBS Congress – ‘Mining biochemistry for human health and well-being’, Jun 2024, Milano, Italy. , 2024. ⟨hal-04923950⟩

Jean Cacheux, Mahla Majidian Eidgahi, Pierre Cordelier. 3D in vitro model of pancreatic cancer to study oncolytic virus infection. Microphysio 2024, Sep 2024, Cargèse, France. 2024. ⟨hal-04746663⟩

Benoît Thibault, Coralie Cayron, Mickael Di-Luoffo, Nicole Therville, Camille Guyon, et al.. PI3K signaling controls metabolic adaptations in pancreatic cancer. EACR Annual Meeting, Jun 2024, Rotterdam, Netherlands. 2024. ⟨hal-04915342⟩

Jade Genetelli, Antoine Naillon, Fabien Mesnilgrente, Pierre Joseph, Marc Prat. Drying of Salt Solutions in Model Porous Media. GDR MicroNanofluidics 2024, Nov 2024, Nice, France. 2024. ⟨hal-04941769⟩

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Signaling, Microenvironment and Targeting - GSO Workshop, Feb 2024, Toulouse, France. 2024. ⟨hal-04917240⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Dialogue between pancreatic tumor and adjacent tissue: a relationship under pressure. Micro-physiological models: From organoids to organs-on-chip, Sep 2024, Cargèse, France. 2024. ⟨hal-04834165⟩

Pré-publications, documents de travail

Antonio Serrano, Charles Puerner, Emily Plumb, Louis Chevalier, Johannes Elferich, et al.. Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen. 2024. ⟨hal-04787785⟩

2023

Articles dans une revue

Jean Cacheux, Aurélien Bancaud, Daniel Alcaide, Jun-Ichi Suehiro, Yoshihiro Akimoto, et al.. Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport. iScience, 2023, 26 (7), pp.107141. ⟨10.1016/j.isci.2023.107141⟩. ⟨hal-04250976⟩

Victor Fournié, Bastien Venzac, Emmanuelle Trevisiol, Julie Foncy, Julien Roul, et al.. A microfluidics-assisted photopolymerization method for high-resolution multimaterial 3D printing. Additive Manufacturing, 2023, 72, pp.103629. ⟨10.1016/j.addma.2023.103629⟩. ⟨hal-04116522⟩

Daniel Alcaide, Jean Cacheux, Aurélien Bancaud, Rieko Muramatsu, Yukiko T Matsunaga. Solute transport in the brain tissue: what are the key biophysical parameters tying in vivo and in vitro studies together?. Biomaterials Science, 2023, 10, pp.3450-3460. ⟨10.1039/D3BM00027C⟩. ⟨hal-04063141⟩

Paul Bruand, Inga Tijunelyte, Adrien Castinel, Cécile Donnadieu, Pierre Joseph, et al.. Size Fractionation of Milliliter DNA Samples in Minutes Controlled by an Electric Field of ∼10 V. Analytical Chemistry, 2023, 95 (49), pp.18099-18106. ⟨10.1021/acs.analchem.3c03187⟩. ⟨hal-04322873⟩

Zacchari Ben Meriem, Tiphaine Mateo, Julien Faccini, Céline Denais, Romane Dusfour-Castan, et al.. A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding. Lab on a Chip, 2023, 20, pp.4445-4455. ⟨10.1039/d3lc00313b⟩. ⟨hal-04214597⟩

Liam Holt, Morgan Delarue. Macromolecular crowding: Sensing without a sensor. Current Opinion in Cell Biology, 2023, 85, pp.102269. ⟨10.1016/j.ceb.2023.102269⟩. ⟨hal-04270738⟩

Jean Cacheux, Jose Ordonez-Miranda, Aurélien Bancaud, Laurent Jalabert, Daniel Alcaide, et al.. Asymmetry of tensile versus compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels. Science Advances , 2023, 9 (31), ⟨10.1126/sciadv.adf9775⟩. ⟨hal-04235287⟩

Hedele Zeng, Takanori Sano, Jean Cacheux, Aurélien Bancaud, Jun-Ichi Kawabe, et al.. Capillary Stem Cells Enhance Vascular Barrier Function Revealed by the In Vitro Microvessel Model. Nanobiomedicine, 2023, 15 (2), pp.105-111. ⟨10.11344/nano.15.105⟩. ⟨hal-04715191⟩

Claire Lac, Julie Foncy, Corinne Bousquet, Laurent Malaquin, Morgan Delarue, et al.. Do mechanical forces induce a protumoural dialogue between the tumour and the adjacent healthy tissue?. Pancreatology, 2023, 23, pp.e23. ⟨10.1016/j.pan.2023.06.460⟩. ⟨hal-04729109⟩

Communications dans un congrès

Mickael Di-Luoffo, Silvia Arcucci, Tristan Marty, Nicole Therville, Sanzhar Aitbay, et al.. Mechanics & Genetics of pancreatic cancer Mechanical compressive stress favors selective mutational contexts and intracellular signaling during pancreatic cancer development. PANCREATIC CANCER SYMPOSIUM AFRCP 2023, Oct 2023, Bordeaux, France. ⟨hal-04908777⟩

Mickael Di-Luoffo, Nicole Therville, Silvia Arcucci, Romina D’Angelo, Benoît Thibault, et al.. Impact of mechanical compressive stress on pancreatic cancer progression. Mechanobiology Club of Toulouse, Jan 2023, Toulouse, France. ⟨hal-04908762⟩

Tiphaine Mateo, Morgane Delarue, Fabien Mesnilgrente, Pierre-François Calmon. Lithographie laser bi-photons pour l'impression de moules PDMS dédiés à des applications micro-fluidique. Renatech Litho Gravure, Réseau Renatech, Jan 2023, Lille, France. ⟨hal-04006407⟩

Benoît Thibault, Fernanda Ramos-Delgado, Hala Shalhoub, Camille Guyon, Handschin Charles, et al.. Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation. GSO Annual Meeting, Nov 2023, Arcachon, France. ⟨hal-04915257⟩

Emilie Belot, Marie-Charline Blatche, Fabrice Mathieu, Frank Bardie, Laurent Mazenq, et al.. Development of nanoprobe array technology for high resolution electrophysiology of brain-on-chip. E-MRS (European Materials Research Society), May 2023, Strasbourg, France. ⟨hal-04135485⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. International Pancreatic Cancer Symposium 2023, Oct 2023, Bordeaux, France. ⟨hal-04834780⟩

Autres documents

S. Aitbay, N. Therville, M. Di-Luoffo, H. Shalhoub, Morgan Delarue, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. ⟨hal-04923912⟩

Julie Jambert, Xavier Jacob, Olivier Liot, Nicolas Hengl. Ultrasound-assisted microfluidic filtration cell to control the clogging in porous media. JSUP 2023, Dec 2023, Lyon, France. ⟨hal-04999960⟩

Mohammad Hussein Baz, Lucas Charpin, Coralie Sengenès, Emmanuelle Trévisiol, Anne Marie Gué. Lab-on-a-chip for Isolating Circulating Adipose Stromal Cells: Pre-processing Module. International Symposium on Microscale Separations and Bioanalysis (MSB), May 2023, Tallahassee, Florida, United States. , 2023. ⟨hal-04117613⟩

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Multiscale Mechanobiology of Cells and Cell Systems, France Bio-Imaging Annual Meeting, Dec 2023, Centre de Biologie Intégrative of the UT3 – Paul Sabatier, Toulouse, France. , 2023. ⟨hal-04920614⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Vicious circle between tumor and pancreatic adjacent tissue : the implication of solid stress. 1st Young Scientist Cancer Congress (YS2C), Oct 2023, Toulouse, France. 2023. ⟨hal-04834747⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. European Pancreatic Congress, Jun 2023, Alpbach, Austria. 2023. ⟨hal-04834743⟩

Benoît Thibault, Fernanda Ramos-Delgado, Hala Shalhoub, Camille Guyon, Charles Handschin, et al.. Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation. Biochemical Society: PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. 2023. ⟨hal-04915379⟩

2022

Articles dans une revue

Inga Tijunelyte, Jeffrey Teillet, Paul Bruand, Rémi Courson, Aurélie Lecestre, et al.. Hybridization-based DNA biosensing with a limit of detection of 4 fM in 30 s using an electrohydrodynamic concentration module fabricated by grayscale lithography. Biomicrofluidics, 2022, 16 (4), pp.044111. ⟨10.1063/5.0073542⟩. ⟨hal-03771547⟩

Vincent Gerbaud, Hugues Leiser, Johnny Beaugrand, Bernard Cathala, Carole Molina-Jouve, et al.. Bibliometric survey and network analysis of biomimetics and nature inspiration in engineering science. Bioinspiration and Biomimetics, 2022, 17 (3), pp.031001. ⟨10.1088/1748-3190/ac4f2e⟩. ⟨hal-03561416⟩

Baptiste Alric, Cécile Formosa-Dague, Etienne Dague, Liam J Holt, Morgan Delarue. Macromolecular crowding limits growth under pressure. Nature Physics, 2022, ⟨10.1038/s41567-022-01506-1⟩. ⟨hal-03428857⟩

Marco Laurati, Manlio Tassieri, Gabriel Espinosa, Mónica S N Oliveira, Pierre Joseph. Editorial: Exploring the mechanical properties of soft materials at multiple length scales. Frontiers in Physics, 2022, 10, ⟨10.3389/fphy.2022.1111099⟩. ⟨hal-04740101⟩

Communications dans un congrès

Aurélien Bancaud. Deformation but not convection induced by intraluminal pressure enhances transport through barrier tissues. BTI : first international conference on Blood Tissue Interfaces, Oct 2022, Montpellier, France. ⟨hal-03821260⟩

Jean Cacheux, Aurélien Bancaud, Jose Ordonez-Miranda, Laurent Jalabert, Yukiko T Matsunaga. Collagen matrix remodeling by fibroblasts monitored by interstitial flow metrology. Microphysiological systems: from organoids to organ-on-chip, Apr 2022, Cargèse, France. ⟨hal-03821244⟩

Paul Bruand, Inga Tijunelyte, Frédéric Ginot, Pierre Joseph, Aurélien Bancaud. Purification and size-fractionation of milli-liter DNA samples in minutes using electrohydrodynamic migration. MSB 2022 (Internation Synmposium on Miscroscale Separations and Bioanalysis), Jul 2022, Liège, Belgium. ⟨hal-03818343⟩

Mickael Di-Luoffo, Nicole Therville, Sanzhar Aitbay, Pauline Lefebvre, Morgan Delarue, et al.. La croissance sous pression impacte la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2022, Sep 2022, Paris, France. ⟨hal-04908684⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Les Translationnelles du GSO - Cancer du Pancréas, Dec 2022, Toulouse, France. ⟨hal-04834772⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces promote tumor progression via the establishment of a dialogue between the tumor and adjacent healthy tissue?. Journée de l'Association Française de Recherche sur le Cancer du Pancréas, Oct 2022, Paris, France. ⟨hal-04834760⟩

Mickael Di-Luoffo, Nicole Therville, Benoit Thibault, Morgan Delarue, Julie Guillermet-Guibert. Impact of mechanical compressive stress on pancreatic cancer progression. Axe 1 : voies oncogéniques du cancer, Dec 2022, Toulouse, France. ⟨hal-04908623⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Les forces mécaniques induisent-elles un dialogue protumoral entre la tumeur et le tissu sain adjacent ?. XXXVIème réunion du Club Français du Pancréas, Sep 2022, Paris, France. ⟨hal-04834757⟩

Autres documents

Mohammad Hussein Baz, Lucas Charpin, Audrey Varin, Coralie Sengenès, Emmanuelle Trevisiol, et al.. Lab-on-a-Chip for the isolation of circulating Adipose Stem Cells. GDR Micro Nanofluidics GDR Bio ingénierie des Interfaces, Oct 2022, Paris, France. 2022. ⟨hal-03823431⟩

Sanzhar Aitbay, Nicole Therville, Silvia Arcucci, Pauline Lefebvre, Mickael Di-Luoffo, et al.. PI3Kβ controls mechanical parameters of pancreatic tumours predictive of poor survival.. EMBO | EMBL Symposium Mechanobiology in development and disease, May 2022, Heidelberg, Germany. 2022. ⟨hal-04923995⟩

Claire Lac, Julie Foncy, Morgan Delarue, Corinne Bousquet, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Translationnelles Cancer Pancréatique GSO, Dec 2022, Toulouse, France. 2022. ⟨hal-04834739⟩

Claire Lac, Julie Foncy, Morgan Delarue, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. MICROPHYSIOLOGICAL SYSTEMS from organoids to organ-on-chip, Apr 2022, Cargese, France. 2022. ⟨hal-04834735⟩

Pré-publications, documents de travail

M. Di-Luoffo, C. Schmitter, E.C. Barrere, N. Therville, Morgan Delarue, et al.. The biomechanical context influences the PI3K output signaling in breast and pancreatic cancer cells. 2022. ⟨hal-03808261⟩

Tong Shu, Tamás Szórádi, Gururaj Kidiyoor, Ying Xie, Nora Herzog, et al.. nucGEMs probe the biophysical properties of the nucleoplasm. 2022. ⟨hal-03808263⟩

2021

Articles dans une revue

M. Di-Luoffo, Zacchari Ben-Meriem, P. Lefebvre, Morgan Delarue, Julie Guillermet-Guibert. PI3K functions as a hub in mechanotransduction. Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩. ⟨hal-03252135⟩

Delphine Bordignon, Barbara Lonetti, Christophe Coudret, Pierre Roblin, Pierre Joseph, et al.. Wet spinning of a library of carbohydrate low molecular weight gels. Journal of Colloid and Interface Science, 2021, 603, pp.333 - 343. ⟨10.1016/j.jcis.2021.06.058⟩. ⟨hal-03278411⟩

Venkata Suresh Vajrala, Baptiste Alric, Adrian Laborde, Camille Colin, Emmanuel Suraniti, et al.. Microwell Array Based Opto‐Electrochemical Detections Revealing Co‐Adaptation of Rheological Properties and Oxygen Metabolism in Budding Yeast. Advanced Biology, 2021, 5 (7), pp.2100484. ⟨10.1002/adbi.202100484⟩. ⟨hal-03228340⟩

Laurent Malaquin, Morgan Delarue, Anne Marie Gué. Les « systèmes micro-physiologique » : des outils pour modéliser le vivant. Le petit illustré, regards croisés de chercheur.es, 2021. ⟨hal-03459155⟩

Inga Tijunelyte, Rémi Malbec, Bayan Chami, Jean Cacheux, Christophe Dez, et al.. micro-RNA 21 detection with a limit of 2 pM in 1 min using a size-accordable concentration module operated by electrohydrodynamic actuation. Biosensors and Bioelectronics, 2021, 178, pp.112992. ⟨10.1016/j.bios.2021.112992⟩. ⟨hal-03449104⟩

Communications dans un congrès

Lyne Pillemont, Daniel Guneysu, Wilfrid Boireau, Céline Elie-Caille, Anne Marie Gué. A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS. MicroTAS 2021, Amy E. Herr, Joel Voldman, Oct 2021, Palm Springs, United States. ⟨hal-03514431⟩

Autres documents

Lyne Pillemont, Daniel Guneysu, Wilfrid Boireau, Celine Elie-Caille, Anne Marie Gué. A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS. MicroTAS 2021, Oct 2021, Palm Spring, United States. , MicroTAS 2021, 2021, The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. ⟨hal-03514467⟩

Terence Desclaux, Paul Duru, Pierre Joseph, Morgan Delarue, Olivier Liot. CLOGGING OF A MODEL PORE BY A YEAST SUSPENSION (SACCHAROMYCES CEREVISIAE). Scientific meeting of the Micro-Nano-Fluidics Network GDR MNF, Sep 2021, Toulouse, France. ⟨hal-03384866⟩

Mickael Di-Luoffo, Pauline Lefebvre, Nicole Therville, Morgan Delarue, Julie Guillermet-Guibert. L’impact des contraintes mécaniques compressives sur la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2021, Sep 2021, Lyon, France. 2021. ⟨hal-04908669⟩

2020

Articles dans une revue

Mohand Larbi Mokrane, Terence Desclaux, Jeffrey F. Morris, Pierre Joseph, Olivier Liot. Microstructure of the near-wall layer of filtration-induced colloidal assembly. Soft Matter, 2020, 42, ⟨10.1039/D0SM01143F⟩. ⟨hal-02879712⟩

Ilaria Francesca Rizzuti, Pietro Mascheroni, Silvia Arcucci, Zacchari Ben-Mériem, Audrey Prunet, et al.. Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents. Physical Review Letters, 2020, 125 (12), pp.128103. ⟨10.1103/PhysRevLett.125.128103⟩. ⟨hal-02943906⟩

Marianne Elias, Adrien Dutoya, Adrian Laborde, Aurélie Lecestre, Costanza Montis, et al.. Microfluidic characterization of biomimetic membrane mechanics with an on-chip micropipette. Micro and Nano Engineering, 2020, 8, pp.100064. ⟨10.1016/j.mne.2020.100064⟩. ⟨hal-02937882⟩

Costanza Montis, Pierre Joseph, Chiara Magnani, Alejandro Marín-Menéndez, Francesco Barbero, et al.. Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery. Colloids and Surfaces B: Biointerfaces, 2020, 195, pp.111266. ⟨10.1016/j.colsurfb.2020.111266⟩. ⟨hal-02949343⟩

Nicolas Milon, Juan-Luis Fuentes Rojas, Adrien Castinel, Laurent Bigot, Géraud Bouwmans, et al.. A tunable filter for high molecular weight DNA selection and linked-read sequencing. Lab on a Chip, 2020, 20 (1), pp.175-184. ⟨10.1039/C9LC00965E⟩. ⟨hal-02400601⟩

Bayan Chami, Nicolas Milon, Juan-Luis Fuentes Rojas, Samuel Charlot, Jean-Christophe Marrot, et al.. Single-step electrohydrodynamic separation of 1–150 kbp in less than 5 min using homogeneous glass/adhesive/glass microchips. Talanta, 2020, 217, pp.121013. ⟨10.1016/j.talanta.2020.121013⟩. ⟨hal-03024740⟩

Jeffrey Teillet, Quentin Martinez, Inga Tijunelyte, Bayan Chami, Aurélien Bancaud. Characterization and minimization of band broadening in DNA electrohydrodynamic migration for enhanced size separation. Soft Matter, 2020, 16 (24), pp.5640-5649. ⟨10.1039/D0SM00475H⟩. ⟨hal-03024741⟩

Anaïs Chalard, Morgane Mauduit, Sandrine Assié-Souleille, Pierre Joseph, Laurent Malaquin, et al.. 3D printing of a biocompatible low molecular weight supramolecular hydrogel by dimethylsulfoxide water solvent exchange. Additive Manufacturing, 2020, 33, pp.101162. ⟨10.1016/j.addma.2020.101162⟩. ⟨hal-02540295⟩

Communications dans un congrès

Lac Claire, Julie Foncy, Laurent Malaquin, Corinne Bousquet, Morgan Delarue, et al.. Impact de la mécanique sur le stroma dans le cas du cancer du pancréas. Workshop "Matrice extracellulaire & Cancer", Sep 2020, Toulouse, France. ⟨hal-04834102⟩

Pré-publications, documents de travail

Olivier Liot, Catherine Sempere, Christophe Ybert, Anne-Laure Biance. Coupled electrokinetic transport through a nanoporous membrane: a theoretical approach. 2020. ⟨hal-02900453⟩

Nous collaborons avec plusieurs groupes travaillant en oncologie et en biophysique. Nous portons le projet ERC UnderPressure, et participons à plusieurs projets européens et nationaux de l'ANR. Voir les pages sur les projets de recherche pour plus de détails.

Nous sommes également fortement impliqués dans le Réseau National de Microfluidique GDR Micro Nano Fluidics MNF.

MILE Team

REJOINDRE

Notre équipe de recherche

Pour plus d’informations sur les offres d’emploi, vous pouvez contacter