2026

Articles dans une revue

Antonio Serrano, Charles Puerner, Louis Chevalier, Emily Plumb, Johannes Elferich, et al.. Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth. Nature Microbiology, 2026, 11, pp.169-179. ⟨10.1038/s41564-025-02205-2⟩. ⟨hal-05383988⟩

2025

Articles dans une revue

Diana Valverde-Mendez, Alp M Sunol, Benjamin P Bratton, Morgan Delarue, Jennifer L Hofmann, et al.. Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (4), pp.e2406340121. ⟨10.1073/pnas.2406340121⟩. ⟨hal-04915896⟩

Zacchari Ben Meriem, Moetassem Billah Meksassi, Céline Denais, Julie Guillermet-Guibert, Morgan Delarue. Proportional modulation of proliferation and motility under 2D compressive stress depends on mesenchymal phenotype. European Physical Journal E: Soft matter and biological physics, 2025, 48 (8-9), pp.52. ⟨10.1140/epje/s10189-025-00516-0⟩. ⟨hal-05244623⟩

Hyojun Kim, Morgan Delarue. Dynamic structure of the cytoplasm. Current Opinion in Cell Biology, 2025, 94, pp.102507. ⟨10.1016/j.ceb.2025.102507⟩. ⟨hal-05244633⟩

Mickaël Di-Luoffo, Céline Schmitter, Emma C Barrere, Nicole Therville, Maria Chaouki, et al.. Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells. Life Science Alliance, 2025, 8 (3), pp.e202402854. ⟨10.26508/lsa.202402854⟩. ⟨hal-04874687⟩

Morgan Delarue. Spatial confinement and life under pressure from physiology to pathology. npj Biological Physics and Mechanics, 2025, 2 (1), pp.8. ⟨10.1038/s44341-025-00013-7⟩. ⟨hal-05244640⟩

Communications dans un congrès

Laurent Mazenq, Pierre-François Calmon, Adrian Laborde, Franck Carcenac, Aurélie Lecestre, et al.. Conventional micro and nanofabrication techniques and processes. Bordeaux Summer School - Innovative technologies and clinical applications in cancer research, Université de Bordeaux, Jun 2025, Bordeaux, France. ⟨hal-05146880⟩

Mickael Di-Luoffo, Silvia Arcucci, Tristan Marty, Nicole Therville, Sanzhar Aitbay, et al.. Impact of mechanical compressive stress on pancreatic cancer progression. de Duve institut (Brussels), de Duve institut, Jun 2025, Bruxelles, Belgium. ⟨hal-05301039⟩

Pré-publications, documents de travail

Mickael Di-Luoffo, Silvia Arcucci, Nicole Therville, Tristan Marty, Romina D’Angelo, et al.. Mutants of p53 sustain tumor growth under mechanical compression. 2025. ⟨hal-05346744⟩

2024

Articles dans une revue

Sylvain Landiech, Marianne Elias, Pierre Lapèze, Hajar Ajiyel, Marine Plancke, et al.. Parallel on-chip micropipettes enabling quantitative multiplexed characterization of vesicle mechanics and cell aggregates rheology. APL Bioengineering, 2024, 8 (2), pp.026122. ⟨10.1063/5.0193333⟩. ⟨hal-04616249⟩

Thomas Perros, Anaïs Biquet-Bisquert, Zacchari Ben Meriem, Morgan Delarue, Pierre Joseph, et al.. Mechanical characterization of regenerating Hydra tissue spheres. Biophysical Journal, 2024, 123 (13), pp.1792-1803. ⟨10.1016/j.bpj.2024.05.022⟩. ⟨hal-04668523⟩

Terence Desclaux, Leonardo Santana, Inès Verdeille, Paul Duru, Pierre Joseph, et al.. Hydrodynamic resistance of a yeast clog. Physical Review Fluids, 2024, 9 (3), pp.034202. ⟨10.1103/PhysRevFluids.9.034202⟩. ⟨hal-04224639v4⟩

Hyojun Kim, Baptiste Alric, Nolan Chan, Julien Roul, Morgan Delarue. Intracellular dry mass density increases under growth-induced pressure. Open Research Europe, 2024, 4, pp.231. ⟨10.12688/openreseurope.18557.2⟩. ⟨hal-04915889⟩

Communications dans un congrès

Romina D’Angelo, Silvia Arcucci, Nicole Therville, Celine Denais, Morgan Delarue, et al.. Imaging the 3D cellular effects of compression in oncology: Application in pancreatic cancer. Atelier pour le 1st meeting of the France-BioImaging Mechanobiology WG, Mechanobiology Working Group FBI, Dec 2024, Toulouse, France. ⟨hal-04908796⟩

Sanzhar Aitbay, Hala Shalhoub, Romina D’Angelo, Nicole Therville, Silvia Arcucci, et al.. Mechanical stress & signal integration by PI3Ks for the control of tumour growth.. 4th PIPgen annual meeting, PIPgen, Sep 2024, Cambridge, United Kingdom. ⟨hal-04924047⟩

Claire Lac, Pauline Thomas, Julie Foncy, Marjorie Fanjul, Laurent Malaquin, et al.. Tumoral mechanical stress reprograms adjacent tissue micro-environment to fuel pancreatic tumor progression: identification of a new subtype of activated fibroblasts.. Journée de l'Association Française pour la Recherche sur le Cancer du Pancréas., Sep 2024, Toulouse, France. ⟨hal-04834786⟩

Autres documents

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Dialogue between pancreatic tumor and adjacent tissue: a relationship under pressure. Micro-physiological models: From organoids to organs-on-chip, Sep 2024, Cargèse, France. 2024. ⟨hal-04834165⟩

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Signaling, Microenvironment and Targeting - GSO Workshop, Feb 2024, Toulouse, France. 2024. ⟨hal-04917240⟩

Sanzhar Aitbay, Nicole Therville, Mickael Di-Luoffo, Hala Shalhoub, Romina D’Angelo, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. 48th FEBS Congress – ‘Mining biochemistry for human health and well-being’, Jun 2024, Milano, Italy. , 2024. ⟨hal-04923950⟩

Comptes rendus de conférences

Sanzhar Aitbay, Nicole Therville, Morgan Delarue, Julie Guillermet-Guibert. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K-MAPK interdynamics. FEBS Congress, Jun 2024, Milano, Italy. FEBS Open Bio, 14, pp.294-294, 2024. ⟨hal-05028933⟩

Pré-publications, documents de travail

Antonio Serrano, Charles Puerner, Emily Plumb, Louis Chevalier, Johannes Elferich, et al.. Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen. 2024. ⟨hal-04787785⟩

Laure Le Blanc, Baptiste Alric, Romain Rollin, Laura Xénard, Laura Ramirez Finn, et al.. Bacterial growth under confinement requires transcriptional adaptation to resist metabolite-induced turgor pressure build-up. 2024. ⟨hal-05346757⟩

2023

Articles dans une revue

Claire Lac, Julie Foncy, Corinne Bousquet, Laurent Malaquin, Morgan Delarue, et al.. Do mechanical forces induce a protumoural dialogue between the tumour and the adjacent healthy tissue?. Pancreatology, 2023, 23, pp.e23. ⟨10.1016/j.pan.2023.06.460⟩. ⟨hal-04729109⟩

Zacchari Ben Meriem, Tiphaine Mateo, Julien Faccini, Céline Denais, Romane Dusfour-Castan, et al.. A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding. Lab on a Chip, 2023, 20, pp.4445-4455. ⟨10.1039/d3lc00313b⟩. ⟨hal-04214597⟩

Liam Holt, Morgan Delarue. Macromolecular crowding: Sensing without a sensor. Current Opinion in Cell Biology, 2023, 85, pp.102269. ⟨10.1016/j.ceb.2023.102269⟩. ⟨hal-04270738⟩

Communications dans un congrès

Tiphaine Mateo, Morgane Delarue, Fabien Mesnilgrente, Pierre-François Calmon. Lithographie laser bi-photons pour l'impression de moules PDMS dédiés à des applications micro-fluidique. Renatech Litho Gravure, Réseau Renatech, Jan 2023, Lille, France. ⟨hal-04006407⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. International Pancreatic Cancer Symposium 2023, Oct 2023, Bordeaux, France. ⟨hal-04834780⟩

Mickael Di-Luoffo, Nicole Therville, Silvia Arcucci, Romina D’Angelo, Benoît Thibault, et al.. Impact of mechanical compressive stress on pancreatic cancer progression. Mechanobiology Club of Toulouse, Jan 2023, Toulouse, France. ⟨hal-04908762⟩

Mickael Di-Luoffo, Silvia Arcucci, Tristan Marty, Nicole Therville, Sanzhar Aitbay, et al.. Mechanics & Genetics of pancreatic cancer Mechanical compressive stress favors selective mutational contexts and intracellular signaling during pancreatic cancer development. PANCREATIC CANCER SYMPOSIUM AFRCP 2023, Oct 2023, Bordeaux, France. ⟨hal-04908777⟩

Autres documents

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Multiscale Mechanobiology of Cells and Cell Systems, France Bio-Imaging Annual Meeting, Dec 2023, Centre de Biologie Intégrative of the UT3 – Paul Sabatier, Toulouse, France. , 2023. ⟨hal-04920614⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. European Pancreatic Congress, Jun 2023, Alpbach, Austria. 2023. ⟨hal-04834743⟩

S. Aitbay, N. Therville, M. Di-Luoffo, H. Shalhoub, Morgan Delarue, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. ⟨hal-04923912⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Vicious circle between tumor and pancreatic adjacent tissue : the implication of solid stress. 1st Young Scientist Cancer Congress (YS2C), Oct 2023, Toulouse, France. 2023. ⟨hal-04834747⟩

2022

Articles dans une revue

Baptiste Alric, Cécile Formosa-Dague, Etienne Dague, Liam J Holt, Morgan Delarue. Macromolecular crowding limits growth under pressure. Nature Physics, 2022, ⟨10.1038/s41567-022-01506-1⟩. ⟨hal-03428857⟩

Communications dans un congrès

Mickael Di-Luoffo, Nicole Therville, Sanzhar Aitbay, Pauline Lefebvre, Morgan Delarue, et al.. La croissance sous pression impacte la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2022, Sep 2022, Paris, France. ⟨hal-04908684⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces promote tumor progression via the establishment of a dialogue between the tumor and adjacent healthy tissue?. Journée de l'Association Française de Recherche sur le Cancer du Pancréas, Oct 2022, Paris, France. ⟨hal-04834760⟩

Mickael Di-Luoffo, Nicole Therville, Benoit Thibault, Morgan Delarue, Julie Guillermet-Guibert. Impact of mechanical compressive stress on pancreatic cancer progression. Axe 1 : voies oncogéniques du cancer, Dec 2022, Toulouse, France. ⟨hal-04908623⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Les forces mécaniques induisent-elles un dialogue protumoral entre la tumeur et le tissu sain adjacent ?. XXXVIème réunion du Club Français du Pancréas, Sep 2022, Paris, France. ⟨hal-04834757⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Les Translationnelles du GSO - Cancer du Pancréas, Dec 2022, Toulouse, France. ⟨hal-04834772⟩

Autres documents

Claire Lac, Julie Foncy, Morgan Delarue, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. MICROPHYSIOLOGICAL SYSTEMS from organoids to organ-on-chip, Apr 2022, Cargese, France. 2022. ⟨hal-04834735⟩

Sanzhar Aitbay, Nicole Therville, Silvia Arcucci, Pauline Lefebvre, Mickael Di-Luoffo, et al.. PI3Kβ controls mechanical parameters of pancreatic tumours predictive of poor survival.. EMBO | EMBL Symposium Mechanobiology in development and disease, May 2022, Heidelberg, Germany. 2022. ⟨hal-04923995⟩

Claire Lac, Julie Foncy, Morgan Delarue, Corinne Bousquet, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Translationnelles Cancer Pancréatique GSO, Dec 2022, Toulouse, France. 2022. ⟨hal-04834739⟩

Thèse de doctorat, Habilitation à diriger des recherches

Morgan Delarue. Confinement spatial et prolifération de cellules sous pression. Biotechnologies. Université toulouse 3 Paul Sabatier, 2022. ⟨tel-04879407⟩

Pré-publications, documents de travail

M. Di-Luoffo, C. Schmitter, E.C. Barrere, N. Therville, Morgan Delarue, et al.. The biomechanical context influences the PI3K output signaling in breast and pancreatic cancer cells. 2022. ⟨hal-03808261⟩

Tong Shu, Tamás Szórádi, Gururaj Kidiyoor, Ying Xie, Nora Herzog, et al.. nucGEMs probe the biophysical properties of the nucleoplasm. 2022. ⟨hal-03808263⟩

2021

Articles dans une revue

M. Di-Luoffo, Zacchari Ben-Meriem, P. Lefebvre, Morgan Delarue, Julie Guillermet-Guibert. PI3K functions as a hub in mechanotransduction. Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩. ⟨hal-03252135⟩

Laurent Malaquin, Morgan Delarue, Anne Marie Gué. Les « systèmes micro-physiologique » : des outils pour modéliser le vivant. Le petit illustré, regards croisés de chercheur.es, 2021. ⟨hal-03459155⟩

Venkata Suresh Vajrala, Baptiste Alric, Adrian Laborde, Camille Colin, Emmanuel Suraniti, et al.. Microwell Array Based Opto‐Electrochemical Detections Revealing Co‐Adaptation of Rheological Properties and Oxygen Metabolism in Budding Yeast. Advanced Biology, 2021, 5 (7), pp.2100484. ⟨10.1002/adbi.202100484⟩. ⟨hal-03228340⟩

Autres documents

Mickael Di-Luoffo, Pauline Lefebvre, Nicole Therville, Morgan Delarue, Julie Guillermet-Guibert. L’impact des contraintes mécaniques compressives sur la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2021, Sep 2021, Lyon, France. 2021. ⟨hal-04908669⟩

Terence Desclaux, Paul Duru, Pierre Joseph, Morgan Delarue, Olivier Liot. CLOGGING OF A MODEL PORE BY A YEAST SUSPENSION (SACCHAROMYCES CEREVISIAE). Scientific meeting of the Micro-Nano-Fluidics Network GDR MNF, Sep 2021, Toulouse, France. ⟨hal-03384866⟩

2020

Articles dans une revue

Ilaria Francesca Rizzuti, Pietro Mascheroni, Silvia Arcucci, Zacchari Ben-Mériem, Audrey Prunet, et al.. Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents. Physical Review Letters, 2020, 125 (12), pp.128103. ⟨10.1103/PhysRevLett.125.128103⟩. ⟨hal-02943906⟩

Communications dans un congrès

Lac Claire, Julie Foncy, Laurent Malaquin, Corinne Bousquet, Morgan Delarue, et al.. Impact de la mécanique sur le stroma dans le cas du cancer du pancréas. Workshop "Matrice extracellulaire & Cancer", Sep 2020, Toulouse, France. ⟨hal-04834102⟩

2018

Chapitres d’ouvrages

Liam J. Holt, O Hallatschek, Morgan Delarue. Mechano-chemostats to study the effects of compressive stress on yeast. Microfluidics in Cell Biology Part B: Microfluidics in Single Cells, 147, pp.215-231, 2018, Methods in Cell Biology, 978-0-12-814282-0. ⟨10.1016/bs.mcb.2018.06.010⟩. ⟨hal-01886064⟩