Mechanobiology and biofluidics

- mechabiofluidics -


MECABIOFLUIDICS team addresses biophysics-related scientific questions thanks to microfluidic technologies. We focus on the interplay between permeability, mechanical properties, and biological activity of tissues and cells. Applications range from the role of mechanics in cancer to filtration, and cell sorting in the blood.


HEAD

Morgan Delarue

PHD DELEGATE

Michaël Toublanc

We address biophysics-related scientific questions thanks to microfluidic technologies. See our Research topics below.

(Bio)filtration-on-chip, or how to study microscale filtration mechanisms.

We use microfluidic models of filtration membranes to study bio-clogging.

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Microvasculature on chip: deformation, permeation and immunomodulation of lymphatic and blood vessels

We study the barrier and immunomodulation functions of vascular tissues with organ-on-chip technologies.

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Impact of spatial confinement on cell physiology

We use microfluidics to study the impact of confinement on the behavior of living cells.

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Cells and extracellular vesicles: Microfluidics for their purification and the analysis of their nucleic acid composition

We develop microfluidic technologies for purifying cells and extracellular vesicles.

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Mechanics of multicellular aggregates, and their interactions with nanoparticles

We develop an original fluidic technology for measuring the mechanical properties of cell aggregates (micropipettes on a chip), fundamental to many biological processes.

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Latest publications

2025

Journal articles

Saharnaz Sarlak, Delphine Marotte, Jessy Sirera, Arthur Karaulic, Alessandra Pierantoni, et al.. Comparative impact of proton versus photon irradiation on triple‐negative breast cancer: Role of VEGFC in tumour aggressiveness. Clinical and Translational Medicine, 2025, 15 (5), pp.2001-1326. ⟨10.1002/ctm2.70330⟩. ⟨hal-05261609⟩

Diana Valverde-Mendez, Alp M Sunol, Benjamin P Bratton, Morgan Delarue, Jennifer L Hofmann, et al.. Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (4), pp.e2406340121. ⟨10.1073/pnas.2406340121⟩. ⟨hal-04915896⟩

Aurélien Bancaud, Tadaaki Nakajima, Jun-Ichi Suehiro, Baptiste Alric, Florent Morfoisse, et al.. Intraluminal pressure triggers a rapid and persistent reinforcement of endothelial barriers. Lab on a Chip, 2025, 8, ⟨10.1039/D5LC00104H⟩. ⟨hal-05018080⟩

Mohammad-H. Baz, Marion Valette, Mireille André, Audrey Varin, Emmanuelle Trevisiol, et al.. Isolation of adipose stromal cells from blood using a two-step microfluidic platform ASCfinder. Scientific Reports, 2025, 15 (1), pp.10471. ⟨10.1038/s41598-025-94353-y⟩. ⟨hal-05007797⟩

Mickaël Di-Luoffo, Céline Schmitter, Emma C Barrere, Nicole Therville, Maria Chaouki, et al.. Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells. Life Science Alliance, 2025, 8 (3), pp.e202402854. ⟨10.26508/lsa.202402854⟩. ⟨hal-04874687⟩

Antonio Serrano, Charles Puerner, Louis Chevalier, Emily Plumb, Johannes Elferich, et al.. Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth. Nature Microbiology, 2025, ⟨10.1038/s41564-025-02205-2⟩. ⟨hal-05383988⟩

Zacchari Ben Meriem, Moetassem Billah Meksassi, Céline Denais, Julie Guillermet-Guibert, Morgan Delarue. Proportional modulation of proliferation and motility under 2D compressive stress depends on mesenchymal phenotype. European Physical Journal E: Soft matter and biological physics, 2025, 48 (8-9), pp.52. ⟨10.1140/epje/s10189-025-00516-0⟩. ⟨hal-05244623⟩

Jeffrey Teillet, Anne Pradines, Naima Hanoun, Jules Edwards, Pierre Joseph, et al.. Detection of EGFR mutations at pM concentration in ten minutes using a microfluidic concentration and separation module. Biomedical Microdevices, 2025, 27 (3), pp.40. ⟨10.1007/s10544-025-00767-w⟩. ⟨hal-05261630⟩

Hyojun Kim, Morgan Delarue. Dynamic structure of the cytoplasm. Current Opinion in Cell Biology, 2025, 94, pp.102507. ⟨10.1016/j.ceb.2025.102507⟩. ⟨hal-05244633⟩

Morgan Delarue. Spatial confinement and life under pressure from physiology to pathology. npj Biological Physics and Mechanics, 2025, 2 (1), pp.8. ⟨10.1038/s44341-025-00013-7⟩. ⟨hal-05244640⟩

Jean Cacheux, Thomas Quénan, Daniel Alcaide, Jose Ordonez-Miranda, Laurent Jalabert, et al.. Porohyperelastic modeling of collagen-gel responses to periodic pressure actuation shows that embedded senescent fibroblasts induce tissue softening associated with fibrous-network reorganization. Physical Review Applied, 2025, 24 (6), pp.064015. ⟨10.1103/7c89-529p⟩. ⟨hal-05399336⟩

Conference papers

Laurent Mazenq, Pierre-François Calmon, Adrian Laborde, Franck Carcenac, Aurélie Lecestre, et al.. Conventional micro and nanofabrication techniques and processes. Bordeaux Summer School - Innovative technologies and clinical applications in cancer research, Université de Bordeaux, Jun 2025, Bordeaux, France. ⟨hal-05146880⟩

Mickael Di-Luoffo, Silvia Arcucci, Tristan Marty, Nicole Therville, Sanzhar Aitbay, et al.. Impact of mechanical compressive stress on pancreatic cancer progression. de Duve institut (Brussels), de Duve institut, Jun 2025, Bruxelles, Belgium. ⟨hal-05301039⟩

Aurélien Bancaud. Transport and deformation in soft / porous tissues: mechanisms and opportunities. Euralimms 2025, Jun 2025, Porquerolles (Hyères), France. ⟨hal-05385339⟩

Michael Toublanc, Aurélien Bancaud, Audrey Boutonnet, Frédéric Ginot. Exploring Extracellular Vesicle–Associated Plasma Cell-Free DNA Structure for Agnostic Biomarker Identification. Extracellular Vesicles in Occitanie: from cell biology to translational medicine, Cancéropole Grand Sud Ouest, Oct 2025, Toulouse, France. ⟨hal-05385208⟩

Other documents

Thomas Quénan, Pierre Cordelier, Yukiko Matsunaga, Aurélien Bancaud, Jean Cacheux. Poromechanics of hydrogels: towards understanding colloidal transport into tissue-on-chip. Euralimms 2025, Jun 2025, Hyères, France. ⟨hal-05457641⟩

Michael Toublanc, Frédéric Ginot, Audrey Boutonnet, Aurélien Bancaud. Exploring Plasma Cell-Free DNA Structure for Agnostic Biomarker Identification. 47th Annual Meeting of the International Society of Oncology and Biomarkers (ISOBM), Oct 2025, Murnau, Germany. ⟨hal-05385257⟩

Preprints, Working Papers, ...

Mickael Di-Luoffo, Silvia Arcucci, Nicole Therville, Tristan Marty, Romina D’Angelo, et al.. Mutants of p53 sustain tumor growth under mechanical compression. 2025. ⟨hal-05346744⟩

2024

Journal articles

Hyojun Kim, Baptiste Alric, Nolan Chan, Julien Roul, Morgan Delarue. Intracellular dry mass density increases under growth-induced pressure. Open Research Europe, 2024, 4, pp.231. ⟨10.12688/openreseurope.18557.2⟩. ⟨hal-04915889⟩

Sylvain Landiech, Marianne Elias, Pierre Lapèze, Hajar Ajiyel, Marine Plancke, et al.. Parallel on-chip micropipettes enabling quantitative multiplexed characterization of vesicle mechanics and cell aggregates rheology. APL Bioengineering, 2024, 8 (2), pp.026122. ⟨10.1063/5.0193333⟩. ⟨hal-04616249⟩

Thomas Perros, Anaïs Biquet-Bisquert, Zacchari Ben Meriem, Morgan Delarue, Pierre Joseph, et al.. Mechanical characterization of regenerating Hydra tissue spheres. Biophysical Journal, 2024, 123 (13), pp.1792-1803. ⟨10.1016/j.bpj.2024.05.022⟩. ⟨hal-04668523⟩

Jean Cacheux, Tadaaki Nakajima, Daniel Alcaide, Takanori Sano, Kotaro Doi, et al.. Protocol for fabricating and characterizing microvessel-on-a-chip for human umbilical vein endothelial cells. STAR Protocols, 2024, 5 (2), pp.102950. ⟨10.1016/j.xpro.2024.102950⟩. ⟨hal-04715098⟩

Daniel Alcaide, Baptiste Alric, Jean Cacheux, Shizuka Nakano, Kotaro Doi, et al.. Laminin and hyaluronan supplementation of collagen hydrogels enhances endothelial function and tight junction expression on three-dimensional cylindrical microvessel-on-a-chip. Biochemical and Biophysical Research Communications, 2024, 724 (6), pp.150234. ⟨10.1016/j.bbrc.2024.150234⟩. ⟨hal-04715111⟩

Terence Desclaux, Leonardo Santana, Inès Verdeille, Paul Duru, Pierre Joseph, et al.. Hydrodynamic resistance of a yeast clog. Physical Review Fluids, 2024, 9 (3), pp.034202. ⟨10.1103/PhysRevFluids.9.034202⟩. ⟨hal-04224639v4⟩

Book sections

Audrey Boutonnet, Inga Tijunelyte, Aurélien Bancaud, Frédéric Ginot. DNA Sizing with pg/μL Sensitivity for Cell-Free DNA Analysis with the μLAS Technology. Microfluidics Diagnostics, 2804, Springer US, pp.53-64, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3850-7_2⟩. ⟨hal-04783449⟩

Conference papers

Romina D’Angelo, Silvia Arcucci, Nicole Therville, Celine Denais, Morgan Delarue, et al.. Imaging the 3D cellular effects of compression in oncology: Application in pancreatic cancer. Atelier pour le 1st meeting of the France-BioImaging Mechanobiology WG, Mechanobiology Working Group FBI, Dec 2024, Toulouse, France. ⟨hal-04908796⟩

Claire Lac, Pauline Thomas, Julie Foncy, Marjorie Fanjul, Laurent Malaquin, et al.. Tumoral mechanical stress reprograms adjacent tissue micro-environment to fuel pancreatic tumor progression: identification of a new subtype of activated fibroblasts.. Journée de l'Association Française pour la Recherche sur le Cancer du Pancréas., Sep 2024, Toulouse, France. ⟨hal-04834786⟩

Mickael Di-Luoffo. Oral bacteria accelerate pancreatic cancer development in mice. 38ième réunion du Club Français du Pancréas, Sep 2024, Toulouse, France. ⟨hal-04908702⟩

Sanzhar Aitbay, Hala Shalhoub, Romina D’Angelo, Nicole Therville, Silvia Arcucci, et al.. Mechanical stress & signal integration by PI3Ks for the control of tumour growth.. 4th PIPgen annual meeting, PIPgen, Sep 2024, Cambridge, United Kingdom. ⟨hal-04924047⟩

Other documents

Benoît Thibault, Coralie Cayron, Mickael Di-Luoffo, Nicole Therville, Camille Guyon, et al.. PI3K signaling controls metabolic adaptations in pancreatic cancer. EACR Annual Meeting, Jun 2024, Rotterdam, Netherlands. 2024. ⟨hal-04915342⟩

Sanzhar Aitbay, Nicole Therville, Mickael Di-Luoffo, Hala Shalhoub, Romina D’Angelo, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. 48th FEBS Congress – ‘Mining biochemistry for human health and well-being’, Jun 2024, Milano, Italy. , 2024. ⟨hal-04923950⟩

Jean Cacheux, Mahla Majidian Eidgahi, Pierre Cordelier. 3D in vitro model of pancreatic cancer to study oncolytic virus infection. Microphysio 2024, Sep 2024, Cargèse, France. 2024. ⟨hal-04746663⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Dialogue between pancreatic tumor and adjacent tissue: a relationship under pressure. Micro-physiological models: From organoids to organs-on-chip, Sep 2024, Cargèse, France. 2024. ⟨hal-04834165⟩

Jade Genetelli, Antoine Naillon, Fabien Mesnilgrente, Pierre Joseph, Marc Prat. Drying of Salt Solutions in Model Porous Media. GDR MicroNanofluidics 2024, Nov 2024, Nice, France. 2024. ⟨hal-04941769⟩

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Signaling, Microenvironment and Targeting - GSO Workshop, Feb 2024, Toulouse, France. 2024. ⟨hal-04917240⟩

Maria Chaouki, Anne Quillet-Mary, Benoît Thibault, Loic Ysebaert, Michael Lahn, et al.. “TREATING B CELL LYMPHOMA PATIENTS WITH INHIBITORS OF PI3Kδ (PHOSPHOINOSITIDE 3-KINASES): how to increase the efficacy?”. 46 th Symposium on Hormones and Cell Regulation, Oct 2024, STRASBOURG (FRANCE), France. ⟨hal-04919848⟩

Proceedings

Sanzhar Aitbay, Nicole Therville, Morgan Delarue, Julie Guillermet-Guibert. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K-MAPK interdynamics. FEBS Congress, Jun 2024, Milano, Italy. FEBS Open Bio, 14, pp.294-294, 2024. ⟨hal-05028933⟩

Preprints, Working Papers, ...

Laure Le Blanc, Baptiste Alric, Romain Rollin, Laura Xénard, Laura Ramirez Finn, et al.. Bacterial growth under confinement requires transcriptional adaptation to resist metabolite-induced turgor pressure build-up. 2024. ⟨hal-05346757⟩

Antonio Serrano, Charles Puerner, Emily Plumb, Louis Chevalier, Johannes Elferich, et al.. Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen. 2024. ⟨hal-04787785⟩

2023

Journal articles

Claire Lac, Julie Foncy, Corinne Bousquet, Laurent Malaquin, Morgan Delarue, et al.. Do mechanical forces induce a protumoural dialogue between the tumour and the adjacent healthy tissue?. Pancreatology, 2023, 23, pp.e23. ⟨10.1016/j.pan.2023.06.460⟩. ⟨hal-04729109⟩

Jean Cacheux, Aurélien Bancaud, Daniel Alcaide, Jun-Ichi Suehiro, Yoshihiro Akimoto, et al.. Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport. iScience, 2023, 26 (7), pp.107141. ⟨10.1016/j.isci.2023.107141⟩. ⟨hal-04250976⟩

Jean Cacheux, Jose Ordonez-Miranda, Aurélien Bancaud, Laurent Jalabert, Daniel Alcaide, et al.. Asymmetry of tensile versus compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels. Science Advances , 2023, 9 (31), ⟨10.1126/sciadv.adf9775⟩. ⟨hal-04235287⟩

Victor Fournié, Bastien Venzac, Emmanuelle Trevisiol, Julie Foncy, Julien Roul, et al.. A microfluidics-assisted photopolymerization method for high-resolution multimaterial 3D printing. Additive Manufacturing, 2023, 72, pp.103629. ⟨10.1016/j.addma.2023.103629⟩. ⟨hal-04116522⟩

Daniel Alcaide, Jean Cacheux, Aurélien Bancaud, Rieko Muramatsu, Yukiko T Matsunaga. Solute transport in the brain tissue: what are the key biophysical parameters tying in vivo and in vitro studies together?. Biomaterials Science, 2023, 10, pp.3450-3460. ⟨10.1039/D3BM00027C⟩. ⟨hal-04063141⟩

Zacchari Ben Meriem, Tiphaine Mateo, Julien Faccini, Céline Denais, Romane Dusfour-Castan, et al.. A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding. Lab on a Chip, 2023, 20, pp.4445-4455. ⟨10.1039/d3lc00313b⟩. ⟨hal-04214597⟩

Liam Holt, Morgan Delarue. Macromolecular crowding: Sensing without a sensor. Current Opinion in Cell Biology, 2023, 85, pp.102269. ⟨10.1016/j.ceb.2023.102269⟩. ⟨hal-04270738⟩

Paul Bruand, Inga Tijunelyte, Adrien Castinel, Cécile Donnadieu, Pierre Joseph, et al.. Size Fractionation of Milliliter DNA Samples in Minutes Controlled by an Electric Field of ∼10 V. Analytical Chemistry, 2023, 95 (49), pp.18099-18106. ⟨10.1021/acs.analchem.3c03187⟩. ⟨hal-04322873⟩

Hedele Zeng, Takanori Sano, Jean Cacheux, Aurélien Bancaud, Jun-Ichi Kawabe, et al.. Capillary Stem Cells Enhance Vascular Barrier Function Revealed by the In Vitro Microvessel Model. Nanobiomedicine, 2023, 15 (2), pp.105-111. ⟨10.11344/nano.15.105⟩. ⟨hal-04715191⟩

Conference papers

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. International Pancreatic Cancer Symposium 2023, Oct 2023, Bordeaux, France. ⟨hal-04834780⟩

Mickael Di-Luoffo, Nicole Therville, Silvia Arcucci, Romina D’Angelo, Benoît Thibault, et al.. Impact of mechanical compressive stress on pancreatic cancer progression. Mechanobiology Club of Toulouse, Jan 2023, Toulouse, France. ⟨hal-04908762⟩

Mickael Di-Luoffo, Silvia Arcucci, Tristan Marty, Nicole Therville, Sanzhar Aitbay, et al.. Mechanics & Genetics of pancreatic cancer Mechanical compressive stress favors selective mutational contexts and intracellular signaling during pancreatic cancer development. PANCREATIC CANCER SYMPOSIUM AFRCP 2023, Oct 2023, Bordeaux, France. ⟨hal-04908777⟩

Benoît Thibault, Fernanda Ramos-Delgado, Hala Shalhoub, Camille Guyon, Handschin Charles, et al.. Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation. GSO Annual Meeting, Nov 2023, Arcachon, France. ⟨hal-04915257⟩

Emilie Belot, Marie-Charline Blatche, Fabrice Mathieu, Frank Bardie, Laurent Mazenq, et al.. Development of nanoprobe array technology for high resolution electrophysiology of brain-on-chip. E-MRS (European Materials Research Society), May 2023, Strasbourg, France. ⟨hal-04135485⟩

Tiphaine Mateo, Morgane Delarue, Fabien Mesnilgrente, Pierre-François Calmon. Lithographie laser bi-photons pour l'impression de moules PDMS dédiés à des applications micro-fluidique. Renatech Litho Gravure, Réseau Renatech, Jan 2023, Lille, France. ⟨hal-04006407⟩

Other documents

S. Aitbay, N. Therville, M. Di-Luoffo, H. Shalhoub, Morgan Delarue, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. ⟨hal-04923912⟩

Benoît Thibault, Fernanda Ramos-Delgado, Hala Shalhoub, Camille Guyon, Charles Handschin, et al.. Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation. Biochemical Society: PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. 2023. ⟨hal-04915379⟩

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Multiscale Mechanobiology of Cells and Cell Systems, France Bio-Imaging Annual Meeting, Dec 2023, Centre de Biologie Intégrative of the UT3 – Paul Sabatier, Toulouse, France. , 2023. ⟨hal-04920614⟩

Mohammad Hussein Baz, Lucas Charpin, Coralie Sengenès, Emmanuelle Trévisiol, Anne Marie Gué. Lab-on-a-chip for Isolating Circulating Adipose Stromal Cells: Pre-processing Module. International Symposium on Microscale Separations and Bioanalysis (MSB), May 2023, Tallahassee, Florida, United States. , 2023. ⟨hal-04117613⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Vicious circle between tumor and pancreatic adjacent tissue : the implication of solid stress. 1st Young Scientist Cancer Congress (YS2C), Oct 2023, Toulouse, France. 2023. ⟨hal-04834747⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. European Pancreatic Congress, Jun 2023, Alpbach, Austria. 2023. ⟨hal-04834743⟩

Mohammad Hussein Baz, Lucas Charpin, Coralie Sengenès, Emmanuelle Trevisiol, Anne Marie Gué. Lab-on-a-Chip for the isolation of circulating Adipose Stem Cells. GDR Micro Nano Fluidics MNF, Apr 2023, Lyon, France. 2023. ⟨hal-05215273⟩

2022

Journal articles

Inga Tijunelyte, Jeffrey Teillet, Paul Bruand, Rémi Courson, Aurélie Lecestre, et al.. Hybridization-based DNA biosensing with a limit of detection of 4 fM in 30 s using an electrohydrodynamic concentration module fabricated by grayscale lithography. Biomicrofluidics, 2022, 16 (4), pp.044111. ⟨10.1063/5.0073542⟩. ⟨hal-03771547⟩

Baptiste Alric, Cécile Formosa-Dague, Etienne Dague, Liam J Holt, Morgan Delarue. Macromolecular crowding limits growth under pressure. Nature Physics, 2022, ⟨10.1038/s41567-022-01506-1⟩. ⟨hal-03428857⟩

Vincent Gerbaud, Hugues Leiser, Johnny Beaugrand, Bernard Cathala, Carole Molina-Jouve, et al.. Bibliometric survey and network analysis of biomimetics and nature inspiration in engineering science. Bioinspiration and Biomimetics, 2022, 17 (3), pp.031001. ⟨10.1088/1748-3190/ac4f2e⟩. ⟨hal-03561416⟩

Marco Laurati, Manlio Tassieri, Gabriel Espinosa, Mónica S N Oliveira, Pierre Joseph. Editorial: Exploring the mechanical properties of soft materials at multiple length scales. Frontiers in Physics, 2022, 10, ⟨10.3389/fphy.2022.1111099⟩. ⟨hal-04740101⟩

Conference papers

Mickael Di-Luoffo, Nicole Therville, Sanzhar Aitbay, Pauline Lefebvre, Morgan Delarue, et al.. La croissance sous pression impacte la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2022, Sep 2022, Paris, France. ⟨hal-04908684⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces promote tumor progression via the establishment of a dialogue between the tumor and adjacent healthy tissue?. Journée de l'Association Française de Recherche sur le Cancer du Pancréas, Oct 2022, Paris, France. ⟨hal-04834760⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Les forces mécaniques induisent-elles un dialogue protumoral entre la tumeur et le tissu sain adjacent ?. XXXVIème réunion du Club Français du Pancréas, Sep 2022, Paris, France. ⟨hal-04834757⟩

Aurélien Bancaud. Deformation but not convection induced by intraluminal pressure enhances transport through barrier tissues. BTI : first international conference on Blood Tissue Interfaces, Oct 2022, Montpellier, France. ⟨hal-03821260⟩

Jean Cacheux, Aurélien Bancaud, Jose Ordonez-Miranda, Laurent Jalabert, Yukiko T Matsunaga. Collagen matrix remodeling by fibroblasts monitored by interstitial flow metrology. Microphysiological systems: from organoids to organ-on-chip, Apr 2022, Cargèse, France. ⟨hal-03821244⟩

Paul Bruand, Inga Tijunelyte, Frédéric Ginot, Pierre Joseph, Aurélien Bancaud. Purification and size-fractionation of milli-liter DNA samples in minutes using electrohydrodynamic migration. MSB 2022 (Internation Synmposium on Miscroscale Separations and Bioanalysis), Jul 2022, Liège, Belgium. ⟨hal-03818343⟩

Mickael Di-Luoffo, Nicole Therville, Benoit Thibault, Morgan Delarue, Julie Guillermet-Guibert. Impact of mechanical compressive stress on pancreatic cancer progression. Axe 1 : voies oncogéniques du cancer, Dec 2022, Toulouse, France. ⟨hal-04908623⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Les Translationnelles du GSO - Cancer du Pancréas, Dec 2022, Toulouse, France. ⟨hal-04834772⟩

Other documents

Claire Lac, Julie Foncy, Morgan Delarue, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. MICROPHYSIOLOGICAL SYSTEMS from organoids to organ-on-chip, Apr 2022, Cargese, France. 2022. ⟨hal-04834735⟩

Claire Lac, Julie Foncy, Morgan Delarue, Corinne Bousquet, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Translationnelles Cancer Pancréatique GSO, Dec 2022, Toulouse, France. 2022. ⟨hal-04834739⟩

Sanzhar Aitbay, Nicole Therville, Silvia Arcucci, Pauline Lefebvre, Mickael Di-Luoffo, et al.. PI3Kβ controls mechanical parameters of pancreatic tumours predictive of poor survival.. EMBO | EMBL Symposium Mechanobiology in development and disease, May 2022, Heidelberg, Germany. 2022. ⟨hal-04923995⟩

Mohammad Hussein Baz, Lucas Charpin, Audrey Varin, Coralie Sengenès, Emmanuelle Trevisiol, et al.. Lab-on-a-Chip for the isolation of circulating Adipose Stem Cells. GDR Micro Nanofluidics GDR Bio ingénierie des Interfaces, Oct 2022, Paris, France. 2022. ⟨hal-03823431⟩

Preprints, Working Papers, ...

M. Di-Luoffo, C. Schmitter, E.C. Barrere, N. Therville, Morgan Delarue, et al.. The biomechanical context influences the PI3K output signaling in breast and pancreatic cancer cells. 2022. ⟨hal-03808261⟩

Tong Shu, Tamás Szórádi, Gururaj Kidiyoor, Ying Xie, Nora Herzog, et al.. nucGEMs probe the biophysical properties of the nucleoplasm. 2022. ⟨hal-03808263⟩

2021

Journal articles

M. Di-Luoffo, Zacchari Ben-Meriem, P. Lefebvre, Morgan Delarue, Julie Guillermet-Guibert. PI3K functions as a hub in mechanotransduction. Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩. ⟨hal-03252135⟩

Delphine Bordignon, Barbara Lonetti, Christophe Coudret, Pierre Roblin, Pierre Joseph, et al.. Wet spinning of a library of carbohydrate low molecular weight gels. Journal of Colloid and Interface Science, 2021, 603, pp.333 - 343. ⟨10.1016/j.jcis.2021.06.058⟩. ⟨hal-03278411⟩

Inga Tijunelyte, Rémi Malbec, Bayan Chami, Jean Cacheux, Christophe Dez, et al.. micro-RNA 21 detection with a limit of 2 pM in 1 min using a size-accordable concentration module operated by electrohydrodynamic actuation. Biosensors and Bioelectronics, 2021, 178, pp.112992. ⟨10.1016/j.bios.2021.112992⟩. ⟨hal-03449104⟩

Venkata Suresh Vajrala, Baptiste Alric, Adrian Laborde, Camille Colin, Emmanuel Suraniti, et al.. Microwell Array Based Opto‐Electrochemical Detections Revealing Co‐Adaptation of Rheological Properties and Oxygen Metabolism in Budding Yeast. Advanced Biology, 2021, 5 (7), pp.2100484. ⟨10.1002/adbi.202100484⟩. ⟨hal-03228340⟩

Laurent Malaquin, Morgan Delarue, Anne Marie Gué. Les « systèmes micro-physiologique » : des outils pour modéliser le vivant. Le petit illustré, regards croisés de chercheur.es, 2021. ⟨hal-03459155⟩

Conference papers

Lyne Pillemont, Daniel Guneysu, Wilfrid Boireau, Céline Elie-Caille, Anne Marie Gué. A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS. MicroTAS 2021, Amy E. Herr, Joel Voldman, Oct 2021, Palm Springs, United States. ⟨hal-03514431⟩

Other documents

Terence Desclaux, Paul Duru, Pierre Joseph, Morgan Delarue, Olivier Liot. CLOGGING OF A MODEL PORE BY A YEAST SUSPENSION (SACCHAROMYCES CEREVISIAE). Scientific meeting of the Micro-Nano-Fluidics Network GDR MNF, Sep 2021, Toulouse, France. ⟨hal-03384866⟩

Mickael Di-Luoffo, Pauline Lefebvre, Nicole Therville, Morgan Delarue, Julie Guillermet-Guibert. L’impact des contraintes mécaniques compressives sur la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2021, Sep 2021, Lyon, France. 2021. ⟨hal-04908669⟩

Lyne Pillemont, Daniel Guneysu, Wilfrid Boireau, Celine Elie-Caille, Anne Marie Gué. A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS. MicroTAS 2021, Oct 2021, Palm Spring, United States. , MicroTAS 2021, 2021, The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. ⟨hal-03514467⟩

Texte à modifier dans l’interface d’édition: champ 'rayonnement' de la page Equipe.We collaborate with several groups working on oncology and biophysics. We lead the ERC Project UnderPressure, and participate to several European and National ANR projects. See Research projects pages for details.

We are also strongly involved in the French National Network on Microfluidics GDR Micro Nano Fluidics MNF

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