2025

Journal articles

Diana Valverde-Mendez, Alp M Sunol, Benjamin P Bratton, Morgan Delarue, Jennifer L Hofmann, et al.. Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (4), pp.e2406340121. ⟨10.1073/pnas.2406340121⟩. ⟨hal-04915896⟩

2024

Journal articles

Terence Desclaux, Leonardo Santana, Inès Verdeille, Paul Duru, Pierre Joseph, et al.. Hydrodynamic resistance of a yeast clog. Physical Review Fluids, 2024, 9 (3), pp.034202. ⟨10.1103/PhysRevFluids.9.034202⟩. ⟨hal-04224639v4⟩

Thomas Perros, Anaïs Biquet-Bisquert, Zacchari Ben Meriem, Morgan Delarue, Pierre Joseph, et al.. Mechanical characterization of regenerating Hydra tissue spheres. Biophysical Journal, 2024, 123 (13), pp.1792-1803. ⟨10.1016/j.bpj.2024.05.022⟩. ⟨hal-04668523⟩

Hyojun Kim, Baptiste Alric, Nolan Chan, Julien Roul, Morgan Delarue. Intracellular dry mass density increases under growth-induced pressure. Open Research Europe, 2024, 4, pp.231. ⟨10.12688/openreseurope.18557.2⟩. ⟨hal-04915889⟩

Sylvain Landiech, Marianne Elias, Pierre Lapèze, Hajar Ajiyel, Marine Plancke, et al.. Parallel on-chip micropipettes enabling quantitative multiplexed characterization of vesicle mechanics and cell aggregates rheology. APL Bioengineering, 2024, 8 (2), pp.026122. ⟨10.1063/5.0193333⟩. ⟨hal-04616249⟩

Conference papers

Sanzhar Aitbay, Hala Shalhoub, Romina D’Angelo, Nicole Therville, Silvia Arcucci, et al.. Mechanical stress & signal integration by PI3Ks for the control of tumour growth.. 4th PIPgen annual meeting, PIPgen, Sep 2024, Cambridge, United Kingdom. ⟨hal-04924047⟩

Romina D’Angelo, Silvia Arcucci, Nicole Therville, Celine Denais, Morgan Delarue, et al.. Imaging the 3D cellular effects of compression in oncology: Application in pancreatic cancer. Atelier pour le 1st meeting of the France-BioImaging Mechanobiology WG, Mechanobiology Working Group FBI, Dec 2024, Toulouse, France. ⟨hal-04908796⟩

Claire Lac, Pauline Thomas, Julie Foncy, Marjorie Fanjul, Laurent Malaquin, et al.. Tumoral mechanical stress reprograms adjacent tissue micro-environment to fuel pancreatic tumor progression: identification of a new subtype of activated fibroblasts.. Journée de l'Association Française pour la Recherche sur le Cancer du Pancréas., Sep 2024, Toulouse, France. ⟨hal-04834786⟩

Other documents

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Signaling, Microenvironment and Targeting - GSO Workshop, Feb 2024, Toulouse, France. 2024. ⟨hal-04917240⟩

Sanzhar Aitbay, Nicole Therville, Mickael Di-Luoffo, Hala Shalhoub, Romina D’Angelo, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. 48th FEBS Congress – ‘Mining biochemistry for human health and well-being’, Jun 2024, Milano, Italy. , 2024. ⟨hal-04923950⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Dialogue between pancreatic tumor and adjacent tissue: a relationship under pressure. Micro-physiological models: From organoids to organs-on-chip, Sep 2024, Cargèse, France. 2024. ⟨hal-04834165⟩

Preprints, Working Papers, ...

Antonio Serrano, Charles Puerner, Emily Plumb, Louis Chevalier, Johannes Elferich, et al.. Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen. 2024. ⟨hal-04787785⟩

2023

Journal articles

Zacchari Ben Meriem, Tiphaine Mateo, Julien Faccini, Céline Denais, Romane Dusfour-Castan, et al.. A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding. Lab on a Chip, 2023, 20, pp.4445-4455. ⟨10.1039/d3lc00313b⟩. ⟨hal-04214597⟩

Liam Holt, Morgan Delarue. Macromolecular crowding: Sensing without a sensor. Current Opinion in Cell Biology, 2023, 85, pp.102269. ⟨10.1016/j.ceb.2023.102269⟩. ⟨hal-04270738⟩

Conference papers

Mickael Di-Luoffo, Nicole Therville, Silvia Arcucci, Romina D’Angelo, Benoît Thibault, et al.. Impact of mechanical compressive stress on pancreatic cancer progression. Mechanobiology Club of Toulouse, Jan 2023, Toulouse, France. ⟨hal-04908762⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. International Pancreatic Cancer Symposium 2023, Oct 2023, Bordeaux, France. ⟨hal-04834780⟩

Tiphaine Mateo, Morgane Delarue, Fabien Mesnilgrente, Pierre-François Calmon. Lithographie laser bi-photons pour l'impression de moules PDMS dédiés à des applications micro-fluidique. Renatech Litho Gravure, Réseau Renatech, Jan 2023, Lille, France. ⟨hal-04006407⟩

Mickael Di-Luoffo, Silvia Arcucci, Tristan Marty, Nicole Therville, Sanzhar Aitbay, et al.. Mechanics & Genetics of pancreatic cancer Mechanical compressive stress favors selective mutational contexts and intracellular signaling during pancreatic cancer development. PANCREATIC CANCER SYMPOSIUM AFRCP 2023, Oct 2023, Bordeaux, France. ⟨hal-04908777⟩

Other documents

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?. European Pancreatic Congress, Jun 2023, Alpbach, Austria. 2023. ⟨hal-04834743⟩

Lac Claire, Julie Foncy, Corinne Bousquet, Morgan Delarue, Christine Jean. Vicious circle between tumor and pancreatic adjacent tissue : the implication of solid stress. 1st Young Scientist Cancer Congress (YS2C), Oct 2023, Toulouse, France. 2023. ⟨hal-04834747⟩

S. Aitbay, N. Therville, M. Di-Luoffo, H. Shalhoub, Morgan Delarue, et al.. Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.. PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. ⟨hal-04923912⟩

Romina D’Angelo, Silvia Arcucci, Laetitia Ligat, Nicole Therville, Celine Denais, et al.. Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer. Multiscale Mechanobiology of Cells and Cell Systems, France Bio-Imaging Annual Meeting, Dec 2023, Centre de Biologie Intégrative of the UT3 – Paul Sabatier, Toulouse, France. , 2023. ⟨hal-04920614⟩

2022

Journal articles

Baptiste Alric, Cécile Formosa-Dague, Etienne Dague, Liam J Holt, Morgan Delarue. Macromolecular crowding limits growth under pressure. Nature Physics, 2022, ⟨10.1038/s41567-022-01506-1⟩. ⟨hal-03428857⟩

Conference papers

Mickael Di-Luoffo, Nicole Therville, Sanzhar Aitbay, Pauline Lefebvre, Morgan Delarue, et al.. La croissance sous pression impacte la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2022, Sep 2022, Paris, France. ⟨hal-04908684⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Les forces mécaniques induisent-elles un dialogue protumoral entre la tumeur et le tissu sain adjacent ?. XXXVIème réunion du Club Français du Pancréas, Sep 2022, Paris, France. ⟨hal-04834757⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. Do mechanical forces promote tumor progression via the establishment of a dialogue between the tumor and adjacent healthy tissue?. Journée de l'Association Française de Recherche sur le Cancer du Pancréas, Oct 2022, Paris, France. ⟨hal-04834760⟩

Claire Lac, Julie Foncy, Laurent Malaquin, Morgan Delarue, Corinne Bousquet, et al.. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Les Translationnelles du GSO - Cancer du Pancréas, Dec 2022, Toulouse, France. ⟨hal-04834772⟩

Other documents

Claire Lac, Julie Foncy, Morgan Delarue, Corinne Bousquet, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. Translationnelles Cancer Pancréatique GSO, Dec 2022, Toulouse, France. 2022. ⟨hal-04834739⟩

Sanzhar Aitbay, Nicole Therville, Silvia Arcucci, Pauline Lefebvre, Mickael Di-Luoffo, et al.. PI3Kβ controls mechanical parameters of pancreatic tumours predictive of poor survival.. EMBO | EMBL Symposium Mechanobiology in development and disease, May 2022, Heidelberg, Germany. 2022. ⟨hal-04923995⟩

Claire Lac, Julie Foncy, Morgan Delarue, Christine Jean. 3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue. MICROPHYSIOLOGICAL SYSTEMS from organoids to organ-on-chip, Apr 2022, Cargese, France. 2022. ⟨hal-04834735⟩

PhD thesis, HDR

Morgan Delarue. Confinement spatial et prolifération de cellules sous pression. Biotechnologies. Université toulouse 3 Paul Sabatier, 2022. ⟨tel-04879407⟩

Preprints, Working Papers, ...

M. Di-Luoffo, C. Schmitter, E.C. Barrere, N. Therville, Morgan Delarue, et al.. The biomechanical context influences the PI3K output signaling in breast and pancreatic cancer cells. 2022. ⟨hal-03808261⟩

Tong Shu, Tamás Szórádi, Gururaj Kidiyoor, Ying Xie, Nora Herzog, et al.. nucGEMs probe the biophysical properties of the nucleoplasm. 2022. ⟨hal-03808263⟩

2021

Journal articles

Venkata Suresh Vajrala, Baptiste Alric, Adrian Laborde, Camille Colin, Emmanuel Suraniti, et al.. Microwell Array Based Opto‐Electrochemical Detections Revealing Co‐Adaptation of Rheological Properties and Oxygen Metabolism in Budding Yeast. Advanced Biology, 2021, 5 (7), pp.2100484. ⟨10.1002/adbi.202100484⟩. ⟨hal-03228340⟩

Laurent Malaquin, Morgan Delarue, Anne Marie Gué. Les « systèmes micro-physiologique » : des outils pour modéliser le vivant. Le petit illustré, regards croisés de chercheur.es, 2021. ⟨hal-03459155⟩

M. Di-Luoffo, Zacchari Ben-Meriem, P. Lefebvre, Morgan Delarue, Julie Guillermet-Guibert. PI3K functions as a hub in mechanotransduction. Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩. ⟨hal-03252135⟩

Other documents

Mickael Di-Luoffo, Pauline Lefebvre, Nicole Therville, Morgan Delarue, Julie Guillermet-Guibert. L’impact des contraintes mécaniques compressives sur la progression et le traitement du cancer du pancréas. Club Français du Pancréas 2021, Sep 2021, Lyon, France. 2021. ⟨hal-04908669⟩

Terence Desclaux, Paul Duru, Pierre Joseph, Morgan Delarue, Olivier Liot. CLOGGING OF A MODEL PORE BY A YEAST SUSPENSION (SACCHAROMYCES CEREVISIAE). Scientific meeting of the Micro-Nano-Fluidics Network GDR MNF, Sep 2021, Toulouse, France. ⟨hal-03384866⟩

2020

Journal articles

Ilaria Francesca Rizzuti, Pietro Mascheroni, Silvia Arcucci, Zacchari Ben-Mériem, Audrey Prunet, et al.. Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents. Physical Review Letters, 2020, 125 (12), pp.128103. ⟨10.1103/PhysRevLett.125.128103⟩. ⟨hal-02943906⟩

Conference papers

Lac Claire, Julie Foncy, Laurent Malaquin, Corinne Bousquet, Morgan Delarue, et al.. Impact de la mécanique sur le stroma dans le cas du cancer du pancréas. Workshop "Matrice extracellulaire & Cancer", Sep 2020, Toulouse, France. ⟨hal-04834102⟩

2018

Journal articles

Morgan Delarue, G P Brittingham, S. Pfeffer, I V Surovtsev, S Pinglay, et al.. mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding. Cell, 2018. ⟨hal-02273800⟩

Book sections

Liam J. Holt, O Hallatschek, Morgan Delarue. Mechano-chemostats to study the effects of compressive stress on yeast. Microfluidics in Cell Biology Part B: Microfluidics in Single Cells, 147, pp.215-231, 2018, Methods in Cell Biology, 978-0-12-814282-0. ⟨10.1016/bs.mcb.2018.06.010⟩. ⟨hal-01886064⟩

2017

Journal articles

Morgan Delarue, Daniel Weissman, Oskar Hallatschek. A simple molecular mechanism explains multiple patterns of cell-size regulation. PLoS ONE, 2017. ⟨hal-02273781⟩

Monika E. Dolega, Morgan Delarue, François Ingremeau, Jacques Prost, Antoine Delon, et al.. Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression. Nature Communications, 2017, 8, pp.14056. ⟨10.1038/ncomms14056⟩. ⟨hal-01478721⟩

Morgan Delarue, Gregory Poterewicz, Ori Hoxha, Jessica Choi, Wonjung Yoo, et al.. The SCWISh network is essential for survival under mechanical pressure. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (51), pp.13465-13470. ⟨10.1073/pnas.1711204114⟩. ⟨hal-02273770⟩

Book sections

Fabien Bertillot, Youmna Attieh, Morgan Delarue, Basile Gurchenkov, Stephanie Descroix, et al.. Microfluidic-Based Generation of 3D Collagen Spheres to Investigate Multicellular Spheroid Invasion. 3D cell culture, pp.269-279, 2017. ⟨hal-02273775⟩

2016

Journal articles

Morgan Delarue, Jörn Hartung, Carl Schreck, Pawel Gniewek, Lucy Hu, et al.. Self-Driven Jamming in Growing Microbial Populations. Nature Physics, 2016, 12 (8), pp.762-766. ⟨10.1038/nphys3741⟩. ⟨hal-02273763⟩

2015

Journal articles

N. Podewitz, Morgan Delarue, J. Elgeti. Tissue homeostasis: A tensile state. EPL - Europhysics Letters, 2015, 109 (5), pp.58005. ⟨10.1209/0295-5075/109/58005⟩. ⟨hal-02273755⟩

Sylvain Monnier, Morgan Delarue, Benjamin Brunel, Monika E. Dolega, Antoine Delon, et al.. Effect of an osmotic stress on multicellular aggregates. Methods, 2015, 94, pp.114 - 119. ⟨10.1016/j.ymeth.2015.07.009⟩. ⟨hal-01214623⟩