The blood and lymphatic systems are integral components of the human circulatory system, working together to maintain homeostasis at the body level. The heart generates the pressure to induce blood flow and ensure a continuous supply of essential substances to organs and tissues. The lymphatic system flushes the excess of interstitial fluid, and contributes to the regulation of the immune response, helping to defend the body against infections. We study the barrier and immunomodulation functions of these vascular tissues with organ-on-chip technologies. Vessel-on-a-chip platforms enable us to delineate the consequences of mechanical, hydrodynamical, and biological cues on the endothelium in the healthy and disease context.

Main collaborations

• Yukiko T. Matsunaga (Univ Tokyo)
• Barbara Garmy-Susini (I2MC, Toulouse)
• Fabrice Soncin (SMMiL-E)