Mechanics of multicellular aggregates, and their interactions with nanoparticles

We develop an original fluidic technology for measuring the mechanical properties of cell aggregates (micropipettes on a chip), fundamental to many biological processes.

At the multicellular scale, cell adhesion and deformation govern many biological processes (embryonic morphogenesis, tumor progression, wound healing).

We are developing an original fluidic technology for measuring the mechanical properties of cell aggregates (micropipettes on a chip). The method also enables the spheroids to be subjected to a controlled stimulus (nanoparticles, shear), thus quantifying the penetration and effect of chemicals, nanoparticles or fluid flows.

We also extend the approach to single cells or vesicles.

Mesure sur puce des propriétés mécaniques d'agrégats cellulaires ou de vésicules

Collaborations

C Roux, B Lonetti (SoftMat, Toulouse)
G Plaza, B González-Bermúdez (UPM Madrid)
C Montis, D Berti (CSGI, Univ Florence)

Contracts

Projet EU Staff Exchange "SAMEMULTIPHYS"
Projet Univ Toulouse / Région Occitanie "Innoflow"