Mimicking transport of nanovectors from blood to tumors

In the field of the vectorization of anticancer agents, the drug delivery by polymer carriers is one of the main options; however the process of passage of these objects from the blood vessels to tumors are far from being fully elucidated.

This project, in close collaboration with chemists at IMRCP (Toulouse), physicist at IRPHE (Marseille), and biologists at IPBS (Toulouse), aims to examine the step that allows a certain type of vectors, ie polymersomes (self-assembly made of polymers), to escape the blood stream to get to the tumor. At LAAS, we study thanks to biomimetic channels how nano-object are transported from a main channel to lateral channel through small orifices.

The approach is to study the processes in biomimetic artificial systems, obtained by microfabrication (clean room techniques). Nano-objects are synthesized in partnership with IMRCP laboratory, expert of these self-assemblies.

We carry out experiments to characterize the transfer of nano-objects through nanofluidic junctions mimicking the gaps between cells lining blood vessels. We mainly study the influence of the nature of nano-objects (size, materials) and the solution (ionic strength).

Reference:

Comparison of methods for the fabrication and the characterization of polymer self-assemblies: what are the important parameters?

M Dionzou, A Morère, C Roux, B Lonetti, J-D Marty, C Mingotaud, P Joseph, D Goudounèche, B Payré, M Léonetti, A-F Mingotaud

Soft Matter 12, 2166-2176 (2016)