53documents trouvés
A simple fabrication process for an efficient constriction-based dielectrophoretic continuous flow sorter
S.SALOMON, T.LEICHLE, R.FULCRAND, D.BOURRIER, A.BOUKABACHE, A.M.GUE, L.NICU
NBS, N2IS, TEAM
Manifestation avec acte : IEEE NEMS 2011, Kaohsiung (Taiwan), 20-23 Février 2011, 4p. , N° 11105
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124224A simple fabrication process for an efficient constriction-based dielectrophoretic continuous flow sorter
S.SALOMON, T.LEICHLE, R.FULCRAND, D.BOURRIER, A.BOUKABACHE, A.M.GUE, L.NICU
NBS, N2IS, TEAM
Manifestation avec acte : Conference on Advances in Microfluidics and Nanofluidics and Asian-Pacific International Symposium on Lab on Chip (AMN-APLOC 2011), Singapour (Singapour), 5-7 Janvier 2011, 2p. , N° 11105
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124134Spotted custom lenses to tailor the divergence of vertical-cavity surface-emitting lasers
V.BARDINAL, B.REIG, T.CAMPS, E.DARAN, C.LEVALLOIS, C.VERGNENEGRE, T.LEICHLE, G.ALMUNEAU, J.B.DOUCET
PH, N2IS, TEAM, INSA Rennes, 2I, NBS
Revue Scientifique : IEEE Photonics Technology Letters, Vol.22, N°21, pp.1592-1594, Novembre 2010 , N° 10404
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122865Shortening the diffusion length: real-time sensing with single-pixel resolved kinetics using room-temperature bonded biofunctional nanoslits
T.LEICHLE, K.T.LIAO, C.F.CHOU
NBS, Academia Sinica
Manifestation avec acte : International Conference for Chemistry and Life Sciences (MicroTAS 2010), Groningen (Pays Bas), 3-7 Octobre 2010, pp.494-496 , N° 10820
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Abstract
We demonstrate (1) the compatibility of a bonding process with the use of pre-functionalized surfaces for the fabrication of biofunctional nanochannels and (2) the use of these devices for real-time sensing with single pixel resolved reaction kinetics. Our method relies on the permanent bond between the surfaces of an oxygen-plasma treated poly-silsesquioxane (PSQ) layer and a non-plasma treated pre-biofunctionalized glass chip occurring at room temperature. The implementation of PSQ-based bonding technique onto pre-functionalized nanoslits offers reduced diffusion length during DNA hybridization experiments which demonstrated an improved reaction rate, enabling the ultra-fast detection of target molecules down to single pixels.
Mots-Clés / Keywords
Nanochannels; Bonding method; Biofunctionalization; Biosensor; Reaction kinetics;
Individual blood-cell capture and 2D organisation on microarrays
Y.ROUPIOZ, N.BERTHET, T.LEICHLE, J.B.POURCIEL, P.MAILLEY, S.CORTES, M.B.VILLIERS, P.N.MARCHE, T.LIVACHE, L.NICU
CEA Grenoble, NBS, 2I, IAB
Revue Scientifique : Small, Vol.5, N°13, pp.1493-1497, Juillet 2009 , N° 09901
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121026Biosensors and tools for surface functionalization from the macro to the nanoscale: the way forward
L.NICU, T.LEICHLE
NBS, Academia Sinica
Revue Scientifique : Journal of Applied Physics, Vol.104, N°11, pp.111101-1-111101-16, Décembre 2008 , N° 08326
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Abstract
Most of review articles or even books dedicated to biosensing issues are organized by the generally admitted scheme of a biosensor. Subsequently, biological receptors, modified surfaces (and ways to specifically modify those surfaces using established biological and/or chemical recipes) and transduction techniques are thoroughly addressed in this precise order. In this review, we deliberately decided to break the conventional way of providing biosensing review by uniquely addressing biomolecules immobilization methods onto a solid surface and biosensing-related transduction techniques. The aim of this review is to provide a contemporary snapshot of the biosensing landscape without neglecting the seminal references or products where needed. The main guiding line of the review is the downscaling (from the macro- to the nanoscale) of biosensors and their respective most known applications. To conclude, a brief overview of the most popularized nanodevices applied to biology is given before attempting to comment on biosensors comparison criteria in terms of targeted applications.
Mots-Clés / Keywords
Biosensors; bioMEMS; Nanobiotechnology; biopatterning;
VCSEL collimation using self-aligned integrated polymer microlenses
C.LEVALLOIS, V.BARDINAL, T.CAMPS, T.LEICHLE, E.DARAN, J.B.DOUCET, C.VERGNENEGRE
N2IS, TEAM, 2I, NBS, PH
Revue Scientifique : Proceedings of SPIE. Micro-Optics, VCSELs, and Photonic Interconnects II: Fabrication, Packaging, and Integration , Vol.9692, 6992-Wp., Octobre 2008 , N° 08174
Lien : http://hal.archives-ouvertes.fr/hal-00489082/fr/
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Mots-Clés / Keywords
micro-optics; Polymers; Microcantilevers; SU-8; VCSEL;
Self-centered polymer microlenses deposited on SU-8 patterned surfaces by means of a cantilever-based spotter
V.BARDINAL, T.CAMPS, C.LEVALLOIS, T.LEICHLE, B.REIG, J.B.DOUCET, E.DARAN, C.VERGNENEGRE
PH, N2IS, INSA Rennes, NBS, TEAM, 2I
Manifestation avec acte : EOS Annual Meeting 2008, Paris (France), 29 Septembre - 2 Octobre 2008, 2p. , N° 08829
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117824Emerging biopatterning methods for fabricating biochips
C.BERGAUD , T.LEICHLE, D.SAYA, F.MATHIEU, J.B.POURCIEL, L.NICU
NBS, 2I
Manifestation sans acte : 2nd Label-Free Protein Array Workshop, Cachan (France), 3-4 Juillet 2008, 1p. (Résumé) , N° 08365
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114457Antibody surface addressing for individual non-adherent living cell capture and organization
Y.ROUPIOZ, N.BERTHET, T.LEICHLE, J.B.POURCIEL, P.MAILLEY, T.LIVACHE, L.NICU
CEA Grenoble, 2I, Academia Sinica, NBS
Rapport LAAS N°08315, Juin 2008, 17p.
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Mots-Clés / Keywords
Surface patterning; Cell microarray; Microcantilevers; Electrochemical deposition; Blood cells;