Laboratoire d’analyse et d’architecture des systèmes
Y.CHARLON, A.PIAU, D.BRULIN, E.CAMPO
S4M, CHU Toulouse
Rapport LAAS N°17093, Avril 2017, 10p.
N.VIGOUROUX, E.CAMPO, C.GRIMAUD, F.VELLA, E.BOUGEOIS
IRIT-UPS, S4M, AG2R La Mondiale, LERASS
Rapport LAAS N°17097, Avril 2017, 19p.
Y.CHARLON, E.CAMPO, D.BRULIN
Rapport LAAS N°17094, Avril 2017, 19p.
Y.TALBI, D.BRULIN, E.CAMPO, J.Y.FOURNIOLS
Manifestation avec acte : IASTED International Conference on Biomedical Engineering ( BioMed ) 2017 du 20 février au 22 février 2017, Innsbruck (Autriche), Février 2017, 7p. , N° 16464
Transdermal administration might be an interesting alternative to current routes of administration. It is noninvasive, avoids gastric side effects, and improves bioavailability of the molecules. However, due to the low permeability of the stratum corneum, a permeation enhancement strategy is required to make a large number of molecules suitable to this mode of administration. To overcome those limitations and deliver controlled drugs, a smart transdermal drug delivery system is designing. This paper focusses on the study of transdermal iontophoresis permeation of lidocaine hydrochloride (2%, w/w) across pig ear skin. In vitro iontophoresis experiments were conducted using Franz diffusion cells. Anodal iontophoresis was applied for 30 minutes at different current densities. Samples (1 mL) were withdrawn every 30 minutes from the receptor compartment and replaced with a fresh buffer and then analyzed using High Performance Liquid Chromatography (HPLC). Results highlight the relationship between current density, time of stimulation, and amount of lidocaine permeated.
Y.TALBI, D.BRULIN, E.CAMPO, J.Y.FOURNIOLS, B.MARTIN, M.BLANZAT
Manifestation avec acte : IEEE EMBS Conference of Biomedical, Engineering and Sciences ( IECBES ) 0 du 04 décembre au 08 décembre 2016, Kuala Lumpur (Malaisie), Décembre 2016, 6p. , N° 16411
The objective of this study is to determine the effect of iontophoresis on the transport of lidocaine hydrochloride (2%, w/w) across ear pig skin. Our project consists of the development of a transdermal drug delivery system (TDDS). The system is designed as a reusable electronic patch where micropump, reservoir, sensors and Bluetooth communication are integrated. Therefore, quantify the iontophoretic diffusion and investigate the effect of different current densities in enhancing and controlling drug delivery is a primordial step. In vitro iontophoresis experiments were conducted using Franz diffusion cells. Iontophoresis was applied for 30 minutes at current density of 0.25, 0.5 and 0.75 mA/cm2. Samples (1 mL) were withdrawn every 30 minutes from the receptor compartment and replaced with fresh buffer and then analyzed using High Performance Liquid Chromatography (HPLC). The amount of lidocaine HCl delivered was 247 ± 19, 199 ± 14 and 115 ± 7.11 μg/cm2 for 0.75, 0.5 and 0.25 mA/cm2 respectively and 25.6 ± 3.02 μg/cm2 for passive diffusion. The amount is influenced by current density, and could be therefore enhanced, predicted and controlled by those parameters.
A.BOUILLOD, A.COSTES, G.SOTO ROMERO, E.BRUNET, F.GRAPPE
S4M, Toulouse III, FFC, C3S
Manifestation avec acte : International Congress on Sport Sciences Research and Technology Support ( icSPORTS ) 2016 du 07 novembre au 09 novembre 2016, Porto (Portugal), Novembre 2016, 5p. , N° 16333
The present work aimed to assess the validity and reliability of the 3D motion analyzer (Shimano Dynamics Lab, Sittard, Netherland) during laboratory cycling tests in comparison with the Vicon device (Vicon Motion Systems Ltd. Oxford, UK). Three cyclists were required to complete one laboratory cycling test at three different pedalling cadence and at a constant power output. Kinematic measurements were collected simultaneously from 3D motion analyzer and Vicon devices and performed five times for each pedalling cadence. The two systems showed a high reliability with excellent intraclass correlation coefficients for most kinematic variables. Moreover, this system was considered as valid by considering the error due to the initial markers placement. Experts and scientists should use the Vicon system for the purpose of research whereas the 3D motion analyzer could be used for bike fitting.
A.BOUILLOD, L.OGGIANO, G.SOTO ROMERO, E.BRUNET, F.GRAPPE
S4M, NTNU, Trondheim, FFC, C3S
Manifestation avec acte : International Congress on Sport Sciences Research and Technology Support ( icSPORTS ) 2016 du 07 novembre au 09 novembre 2016, Porto (Portugal), Novembre 2016, 6p. , N° 16332
The present work aimed to assess the effective frontal area (AC d , m 2) of a cyclist using both 3D scanning and Computational Fluid Dynamics (CFD) simulation and compare the results with wind tunnel and field measurements. One elite cyclist was recruited to complete a 3D scanning, a wind tunnel test and a field test. The 3D scanning was analyzed using CFD simulation to determine the AC d of the cyclist. The CFD AC d was compared to those measured in both wind tunnel and field tests. The 3D scanning method provides useful data for cycling science and TT position or equipment optimization, by using iterative approach. Indeed, the AC d obtained after CFD simulation was in accordance with those obtained in both wind tunnel and field testing sessions. Resolution, scanning time and post processing are compatible with an extensive use in real conditions and with a larger number of cyclists.
B.HAJJINE, C.ESCRIBA, J.Y.FOURNIOLS
Rapport LAAS N°16352, Novembre 2016, 5p.
N.VIGOUROUX, E.CAMPO, E.BOUGEOIS, J.DUCHIER
IRIT-UPS, S4M, LERASS, INSERM
Manifestation avec acte : Conférence Francophone sur l'Interaction Homme-Machine ( IHM ) 2016 du 25 octobre au 28 octobre 2016, Fribourg (Suisse), Octobre 2016, pp.16-19 , N° 16362
This article presents a multimodal observation method of older people discovering the use of a smart house and tactile and spoken interaction modes inside a Living Lab. Our observation is based on ethnographic and numerical methods. We highlight the impact of presentation of the different technologies on the change of mind, the preference for voice interaction and some brakes considered as far as the adoption of new technologies is concerned.
Rapport LAAS N°16323, Octobre 2016, 126p.